Perry Marshall, Author of “Industrial Ethernet” and Communications Engineer Bill Jenkins give a technical Treatment of Information Theory as it relates to DNA and Evolution.
Some errors: Shapiro’s work was with bacteria, not protozoa. Specific mutations of splicing a single protein under starvation stress increased at least 100,000-fold. Dr. Shapiro was not able to determine how many incorrect evolution mutation attempts were made vs. successful mutations.
The 100,000 breaks come in ciliated protozoa as demonstrated by David Prescott, Laura Landweber, Martin Gorovsky and many others. These edits are highly non-random and RNA-guided, but in this case, there was no change in adaptations. These genome acrobatics go on at each episode of starvation and sexual reproduction. They convert the germline nucleus into a restructured simplified somatic nucleus.